Cholinesterase is an enzyme produced in the liver and secreted into the bloodstream, mainly used to reflect the function of the liver and kidney. Elevated cholinesterase indicates acute and chronic nephritis, hyperlipidemia, etc. Decreased cholinesterase indicates hepatitis, organophosphorus poisoning, etc. The details are as follows.
1. Elevated cholinesterase: As cholinesterase is broken down and excreted through kidney, when acute and chronic nephritis occurs, renal function is impaired, cholinesterase excretion is reduced, and cholinesterase will accumulate and be elevated. Cholinesterase contains low-density lipoprotein, and the serum of patients with hyperlipidemia and fatty liver is high in low-density lipoprotein, so it will lead to an increase in the synthesis of cholinesterase, which will cause the elevation of cholinesterase.
2. Decrease of cholinesterase: Inflammation of hepatocytes will decrease the activity of cholinesterase, and the heavier the inflammation, the more obvious the decrease of enzyme activity. Such as chronic hepatitis, cirrhosis, etc. In organophosphorus poisoning, after the body ingests organophosphorus, the activity of cholinesterase will be inhibited, and the level will be obviously reduced, so the reduction of cholinesterase is also commonly used in the diagnosis of organophosphorus poisoning.
When cholinesterase abnormality occurs, patients need to consult a doctor as soon as possible to clarify the cause and actively carry out the treatment of the original disease.