Liver puncture is generally considered in the presence of liver-occupying lesions, liver abscesses, and to clarify the type of hepatitis. 1. Hepatic space-occupying lesions: Liver puncture biopsy is performed under ultrasound guidance to determine whether the liver space-occupying lesions are benign or malignant. If the pathological findings suggest primary liver cancer or metastatic liver cancer, aggressive anti-tumor therapy is required. 2. Liver abscess: if the patient has systemic symptoms such as liquefaction of abscess, high fever, abdominal pain, etc., it is necessary to perform puncture and drainage of abscess to reduce systemic infection and other complications caused by abscess. 3. Define the type of hepatitis: most of the hepatitis viruses are hepatophilic viruses, which can only be detected by clinical tests when the serum hepatopathy virus reaches a certain amount. So there are still some viral hepatitis that are difficult to identify their pathogens. By liver puncture, it can be used to detect hepatitis viruses parasitized in liver tissue. In the event of liver discomfort, it is recommended to seek medical attention, follow the doctor’s instructions to choose the appropriate test, clarify the cause with the help of the doctor, and carry out targeted treatment or therapy.