A pus-filled big toe thumb does not usually heal on its own. There are more causes of pus in the big toe thumb, the more common being acute onychomycosis and bacterial infections caused by trauma. Inflammation of the tissue around the toenail, may be bacterial or fungal infection, it is difficult to self-cure, if not treated the symptoms will worsen, especially fungal infection may also be infected to other people, the need for local topical medication and systemic medication, if necessary, also need to be surgical incision and drainage or extraction of the nail, regular medication, and take amoxicillin, cefaclor and other antibiotics treatment. If the trauma caused by the big toe pus, considering the combination of bacterial infection, this situation shows that the infection has been more serious, can not blindly expect self healing, need to go to the hospital in time to deal with the wound, if necessary, need to be incised and drainage, and take amoxicillin, cefaclor and other antibiotic treatment. If you have a pus-filled big toe, it is recommended that you go to the hospital in time for regular treatment.