Blisters at the corners of the mouth, most of them are herpes labialis caused by herpes virus infection. Anti-viral drugs can be used for blisters, and topical ones can be used as acyclovir ointment or ribavirin cream. Oral medications can be chosen from Shuanghuanglian oral solution, Budilan oral solution, antiviral oral solution or oral acyclovir tablets, ribavirin tablets, mainly herpes virus infection resulting in blisters, herpes virus infection is easily cross-contagious. If the patient has such blisters, it is recommended that they should use separate utensils, separate towels and other toiletries, and avoid contact with children, who have a low immune system and are prone to herpes virus infection.