The main risk of stones to the kidney is blockage of the urinary tract and direct damage to the mucosa of the urinary tract, leading to decreased kidney function. When complicated by infection, it develops into pyelonephritis or pus accumulation in the kidney, which rapidly impairs the kidney function. Uremia is a syndrome in which creatinine accumulates in the body and causes damage to multiple organ systems throughout the body when kidney function declines and the body is unable to cleanse the toxins produced by creatinine. This syndrome only occurs when both kidneys are severely impaired to less than 33% of total function. Therefore, uremia does not manifest itself when one kidney is failing or when bilateral kidney function is superimposed to maintain daily work, but is very serious when it does. If stones block the ureter and are not treated, the kidney function on this side will be severely impaired, and when stones also develop on the opposite side, the result will be very serious. If the patient is born with a congenital solitary kidney and the opposite kidney has underlying disorders such as tuberculosis, tumor, cyst, spongy kidney, etc., then the arrival of uremic syndrome can be expected. Thus, it seems that uremia and stones are very closely related.