EBV IgA and IgM antibodies have different clinical significance, with positive IgA antibodies suggesting previous infection and positive IgM antibodies suggesting recent infection. Positive EBV IgA antibody suggests that the patient has been infected with EBV in the past, but it is not clear whether the patient has been infected with EBV in the recent past or is currently infected with EBV. In contrast, positive EBV IgM antibodies indicate that the patient has had a recent EBV infection, representing acute and recent infection. Persistent EBV infection is associated with a variety of diseases, such as nasopharyngeal cancer, lymphoma, and infectious mononucleosis, etc. Whether the patient is positive for EBV IgA or IgM antibodies, the patient should be alerted to the presence of any of these diseases in the organism. Therefore, EBV antibody-positive patients should go to the hospital for further consultation and regular treatment under the doctor’s guidance after completing the examination to prevent further progression of the disease.