Lupus erythematosus is a classic autoimmune connective tissue disease with a complex pathogenesis and a genetic correlation. More than 50 genetic loci have been found to be strongly associated with the development of lupus erythematosus. Some patients have a tendency to cluster in their families, and some of their family members also have lupus or other connective tissue diseases, so genetic inheritance plays a very important role in the development of lupus. However, it is not certain that people carrying susceptibility genes will develop lupus erythematosus. Acquired factors are also important, including endocrine, especially sex hormones, which are closely related to the development of lupus erythematosus, and the environment and medications, which are also related to the development of lupus erythematosus. Therefore, the onset of lupus erythematosus is related to carrying susceptibility genes, but it is the result of the long-term joint action of genetic factors and acquired environmental factors, rather than a genetic disease.