Brush your teeth in the morning and cough up sputum with blood, throat discomfort may be caused by infectious mononucleosis, chronic pharyngitis, reflux pharyngitis and so on. 1. Infectious mononucleosis: this disease is caused by EBV infection, mostly seen in children, is an acute or subacute infectious disease. The disease is characterized by irregular fever, inflammation of the throat, enlarged lymph nodes, increased lymphocytes and monocytes in the peripheral blood. In a few cases, the tonsils are particularly enlarged, and large and deep ulcers appear on the surface, which are prone to bleeding, bad breath, throat discomfort, and sputum with blood and other symptoms. 2. Chronic pharyngolaryngitis: chronic pharyngolaryngolaryngitis patient’s throat mucous membrane congestion and redness, so there will be up in the morning to brush the teeth of the throat uncomfortable, because of chronic pharyngolaryngolaryngitis patient’s throat small blood vessels in the vascular wall is relatively fragile, so there will be coughing up sputum with blood. 3. Reflux pharyngitis: the patient will be due to gastric reflux to the throat, gastric acid burns the mucous membrane of the throat leading to bleeding, so will get up in the morning to brush the teeth of the phenomenon of coughing up sputum with blood. Other conditions can also lead to coughing up sputum with blood in the morning brushing teeth, throat uncomfortable symptoms, it is recommended that the patient discomfort in a timely manner to consult a doctor to clarify the cause of the disease, under the guidance of the doctor for the appropriate treatment.