After herpes simplex virus infects the skin and mucous membranes of the genital and anal areas, it usually appears after an incubation period of 2-20 days (average 6 days) on the foreskin, coronal sulcus, glans and penis body in men; and on the labia majora, labia minora, perineum, perianal area and vagina in women, and soon develops into clusters or scattered small blisters, which break into vesicles or ulcers after 2-4 days. Pain, itching, and burning sensation are felt. The duration of the disease lasts 2-3 weeks. The disease may be accompanied by systemic symptoms such as fever, headache, myalgia, general malaise or weakness. There may be manifestations of urethritis, cystitis or cervicitis. Lymph nodes in the groin (i.e., at the root of the thigh) may be enlarged and have pressure pain. If there is a previous history of herpes of the mouth, lips or face, and then re-infected with herpes simplex virus-2, compared to the above symptoms, the conscious symptoms are milder, the rash is smaller, the duration of the disease is shorter, systemic symptoms are rare, and the lymph nodes at the root of the thighs are mostly not enlarged. Recurrent genital herpes mostly appears 1-4 months after the primary infection. The frequency of recurrences varies from person to person, ranging from 3-4 to more than 10 times per year. Recurrence is preceded by local itching, burning, tingling, vague pain, numbness, and perineal swelling for a few hours to a few days. The lesions are small in number and are clusters of small blisters that quickly break down to form vesicles or ulcers, which are asymmetrically distributed and have a slight local itching, pain, and burning sensation. The rash usually heals within a week.