Genital herpes is one of the STDs caused by Herpes Simplex Virus (HSV) types I and II. The incidence has increased significantly in recent years. In China, it is still a new generation member of STD and people do not have enough knowledge about its harmful effects. Herpes simplex virus can cause infections of the skin, mucous membranes and various organs. It can occur through sexual contact with genital herpes. There are two serotypes of genital herpes viruses; HSV-I and HSV-II. The majority of genital herpes is caused by HSV-II, which can have a chronic recurrent course and for which there is no cure. HSV is currently the leading cause of genital ulcers in many countries and regions, and is also associated with the development of cervical cancer and the transmission of neonatal herpes disease. Etiology Herpes simplex virus infection pathology: there is a very small damage to the local mucosa and genital herpes virus enters the local mucosa and causes infection. Symptoms (a) Primary GH: common in the penis, foreskin, glans, coronal sulcus, scrotum and perineum in men; common in the cervix, vagina, urethra, labia and vulvar skin mucosa in women. Before the onset of the disease, there is a slight local redness, burning and tension, followed by the appearance of clusters of small papules and quickly become chestnut-sized blisters, conical, slightly thick wall, herpes fluid clarified at first, later cloudy, often in a cluster, but also two or three clusters, the blisters rupture to reveal the vesicular surface, a few days later dry crust, after healing can be left behind temporary pigmentation, easy to recur in the same place. Some patients may experience lethargy, general malaise, low fever and painful lymphadenopathy in the vicinity. If the rash involves the urethra, symptoms such as painful urination and difficulty in urination may occur. If the rash occurs in the vagina or cervix, there may be no conscious symptoms because the area is relatively insensitive. In a few cases, it may cause disseminated infections such as HSV encephalitis. The primary infection usually lasts for 1 to 2 months before slowly resolving. (b) Recurrent GH: Recurrent symptoms are milder and shorter in duration, usually without systemic symptoms. Before recurrence, there may be prodromal symptoms such as local pruritus, occasional blistering at the site of initial infection, and the formation of vesicles or shallow ulcers, and the rash can subside in 7-10 days. Signs are seen in papules and small blisters at the site of prevalence, which may form pustules after 3 to 5 days, break down to form vesicles and ulcers, and finally heal with scabs. Diagnosis A history of impure sexual intercourse, the occurrence of clusters of blisters in the external genital area, and painful self-conscious symptoms should be examined as follows: 1, herpes smear method: use a cotton swab to scrape the specimen from the base of the blister smear, Wright or Giemsa staining, and find the multinucleated giant cells in the nucleus eosinophilic inclusion body under the light microscope, this method positive rate of 50%. 2. Herpes virus culture: disinfect the herpes membrane with acetone (without alcohol) when taking the material, extract the herpes fluid with a dry needle and place it in a sterilized test tube, send it to the laboratory for culture, and isolate the virus from the tissue culture to establish the diagnosis. This method positive rate of more than 80%, single current culture, isolation of the virus required expensive. 3, indirect fluorescent antibody test: scrape the bottom of the herpes herpes fluid placed on a glass slide. Then add 2 drops of phosphate buffered saline, air dry fixed, stained with free anti-herpes virus serum and fluorescein-labeled anti-free globulin, see positive fluorescence. 4, serological methods: determination of HSVII antibody potency, this method is helpful for primary cases, but not meaningful for recurrent cases.