Blisters on the nose and around the mouth of a five-year-old child may be a herpes simplex virus infection. You can use acyclovir cream for topical application. Also, eat a light diet and exercise properly. A five-year-old child with blisters on his nose and around his mouth may have a herpes simplex virus infection. Acyclovir ointment can be used to apply locally to the lesions. At the same time, you should also pay attention to a light diet and avoid excessive intake of spicy and irritating foods. Otherwise, it may aggravate the condition. In addition, appropriate exercise can improve the body’s immunity, conducive to recovery. Acyclovir ointment may cause localized pain and burning sensation and other adverse reactions. When a five-year-old child develops symptoms of blisters on the nose and around the mouth, parents should be careful not to let the child scratch at will, otherwise it may aggravate the lesions or even secondary infection. Parents need to take their children to the hospital for consultation and targeted treatment after a clear diagnosis.