Creutzfeldt-Jakob disease is a prion disease, which is caused by the infection of prion specific pathogens to the central nervous system, and its characteristic change is the spongy degeneration of brain tissue, and there is no treatment that can be done, and most of them die within one year of the onset of the disease, and there are no cases of long-term survival yet. Creutzfeldt-Jakob disease is treated only symptomatically to save lives and prolong its survival, for example, with obvious symptoms of neurological deficits, seizures, and cognitive impairment, antiepileptic drugs as well as brain-protective drugs can be given. Intravenous antiepileptic drugs, such as sodium valproate continuous pumping, can also be administered in the later stages when there are significant decerebrate or decorticate tonic seizures. Sedatives may be used as well as medications that reduce muscle tone and improve symptoms, such as dopa-like drugs or dopa agonists. In the presence of complications such as pulmonary infection, electrolyte disturbance, and hypoproteinemia, symptomatic treatment, anti-infection, albumin supplementation, electrolyte replacement, and correction of internal environmental disturbances are given. In the presence of respiratory failure at the end stage, tracheotomy, tracheal intubation, or ventilator-assisted breathing may be given.