The key to the treatment of patients with high aminotransferases is to clarify the original cause of the elevated aminotransferases for treatment, and at the same time, some liver-protecting and enzyme-lowering drugs can be added to assist in the treatment according to the condition. Transaminases exist in the human liver, heart muscle, skeletal muscle and other tissue cells, under normal circumstances, the level of transaminases in the blood is very low, when the human body is damaged liver cells and other tissues can be released into the blood, causing transaminases to rise. Therefore, elevated aminotransferases are a sign that certain pathologies exist in the body, and the key to treatment is to treat the primary pathology and stop the continued destruction of tissue cells in order to correct the root cause of elevated aminotransferases. Diseases that cause elevated transaminases include viral hepatitis, alcoholic liver disease, fatty liver, cirrhosis, acute myocardial infarction, dermatomyositis, etc. Patients should seek prompt medical attention to determine the cause of the disease and then adopt a targeted treatment plan. In addition, for abnormal liver function and elevated transaminases, some liver-protecting and enzyme-lowering drugs can be added as appropriate. Clinically, it is common to use enzyme-lowering drugs such as silymarin and dicyclomine or anti-inflammatory and choleretic drugs such as glutathione, ursodeoxycholic acid and glycyrrhetinic acid preparations to achieve the purpose of adjuvant liver-protective treatment. The liver-protecting and enzyme-lowering efficacy of herbal preparations such as Wu Wei Zi and Yin Gardenia Huang is also clearer. In summary, the key to the treatment of patients with high transaminases is to find the cause of the disease for targeted treatment, and at the same time, the above-mentioned liver-protecting and enzyme-lowering drugs can be added appropriately for supplementary treatment.