Gastric drugs and lipid-lowering drugs do not conflict in general, but need to observe and pay attention to the existence of adverse drug reactions, such as gastric drugs may cause flatulence, constipation, liver damage; lipid-lowering drugs caused by liver function damage, elevated blood glucose and so on. And the dosage time of gastric drugs and lipid-lowering drugs is also different, and it is recommended to use them under the guidance of a doctor. Gastric drugs generally include histamine H2 receptor antagonists, proton pump inhibitors, alkaline acid-producing drugs, gastric mucosal protectants, gastric motility drugs, etc., which can inhibit excessive gastric acid secretion, protect the gastric mucosa, promote gastric emptying, generally eaten before meals. Lipid-lowering drugs are mainly statins, which can inhibit cholesterol synthesis through competitive inhibition; Beta drugs promote the decomposition of total cholesterol to lower blood lipids by activating peroxisome proliferator-activator receptors, and are mostly taken before bedtime. According to the drug inserts and available studies, there is no evidence of interaction between gastric drugs and lipid-lowering drugs when used together. However, patients taking gastric drugs and lipid-lowering drugs should be standardized under the guidance of a doctor, do not blindly self-medication, in order to avoid adverse consequences.