Painful and itchy urination may be related to urethritis, glans penis, urethral calculi and other causes. 1. Urethritis: it can be divided into gonococcal urethritis and non-gonococcal urethritis, the clinical manifestations are usually burning, itching and pain at the external urethral opening, which may be accompanied by urinary discharge. 2. Gonorrhea: due to the inflammation of the foreskin or glans, it can cause painful and itchy urination. 3. Urethral calculi: Urethral calculi may damage the mucous membrane of the inner wall of the urethra during the process of moving along with the urine and cause infection, which may result in itching and pain when urinating. There are many reasons for painful and itchy urination, it is recommended to go to the hospital in a timely manner to clarify the cause of the disease, and standardized treatment under the guidance of the doctor, so as not to delay the condition.