Fasting for too long does not usually lead to high bilirubin. Most causes of high bilirubin are liver disease, gallbladder disease, and other causes. 1. Liver disease: For example, various types of hepatitis, drug-induced liver injury, alcoholic liver, fatty liver, etc., may cause liver function to be impaired, resulting in high bilirubin. 2. Biliary tract obstruction: including cholelithiasis, periampullary tumors and other intra- and extra-hepatic biliary tract obstructive diseases, which can also cause high bilirubin. 3. Other causes: such as hemolysis and other causes, can also cause high bilirubin. Fasting for too long does not usually lead to elevated bilirubin, but try not to have a fast for too long to avoid consequences such as hypoglycemia. If you have a high bilirubin, you should go to the hospital for examination in time to clarify the cause of the disease and take appropriate treatment measures as prescribed by the doctor.