Glutamyl transpeptidase 220 U/L requires treatment. Elevated glutamine transpeptidase is seen in cholestasis of various causes and is increased in different liver diseases, such as acute and chronic hepatitis and alcoholic liver damage. Acute hepatitis: when all other liver function indicators have returned to normal, but glutamine transpeptidase has not returned to normal, suggesting residual lesions in the liver, hepatitis has not yet healed. If glutamyl transpeptidase fluctuates repeatedly or maintains a high level for a long time, it is considered that hepatitis has a tendency of slow transition. Chronic hepatitis: In moderate to severe chronic hepatitis, glutamyl transpeptidase can be 1~2 times higher than normal value, and the long-term persistent elevation indicates that the disease has progressed. Alcoholic liver damage: especially in acute alcoholism, glutamyl transpeptidase is often significantly elevated, up to 10 times the normal value. The normal value of glutamyl transpeptidase is between 0~40U/L, so when the glutamyl transpeptidase is 220U/L, it is seriously out of the normal range, and it is recommended to go to the hospital in time for medical treatment under the guidance of professional physicians.