Generalized soreness and weakness and sore throat may be caused by Fanxiang isthmus, acute pharyngitis, acute tonsillitis and other causes. 1. Fanshuang pharyngitis: a subacute tonsillitis infected by Clostridium difficile and Fanshuang spirochete, characterized by markedly limited inflammatory reaction and ulcer formation. The main symptom is sore throat, mostly unilateral, accompanied by headache, back and joint pain, general malaise, may be accompanied by low fever, usually not more than 38.5 ℃. 2. Acute pharyngitis: acute inflammation usually triggered by viral or bacterial infections, which can cause sore throat and other phenomena in the throat, accompanied by generalized soreness and weakness. 3. Acute tonsillitis: during an acute attack of the tonsils, high fever, vomiting and generalized pain and weakness may occur, accompanied by a sore throat. Patients with generalized pain and weakness and sore throat should go to the regular hospital in time to identify the cause of the disease, and under the guidance of professional doctors to carry out targeted treatment.