The main ingredient of Nimesulide granules is Nimesulide, which belongs to the sulfonamide class of non-steroidal anti-inflammatory drugs, with anti-inflammatory, analgesic and antipyretic effects. It is suitable for the treatment of pain and inflammation after surgery and acute trauma; chronic joint inflammation (such as rheumatoid arthritis and osteoarthritis); symptomatic treatment of primary dysmenorrhea; pain caused by inflammation of the ear, nose and throat; fever caused by upper respiratory tract infection, etc. It can relieve and eliminate inflammation with and without pain sensation, as well as inflammation accompanied by fever, such as arthritis and tendonitis. The efficacy and safety of Nimesulide in the treatment of rheumatoid arthritis (RA) have been reported at home and abroad, and it is one of the treatment drugs for rheumatic orthopedic diseases. In 2007, the State Food and Drug Administration evaluated the safety of Nimesulide and revised the instruction manual according to the expert’s opinion, taking restrictive measures, such as prohibiting the use of Nimesulide in children under 1 year old, limiting the dosage of Nimesulide in children, limiting the course of antipyretic treatment in children to 3 days, and adding warning information such as liver function should be monitored for long-term use.