Crystallization of the gallbladder wall is usually not painful, but painful conditions can occur and need to be judged according to the patient’s performance. Gallbladder wall crystals are crystals caused by bile silted up in the gallbladder for a long time, most of them are cholesterol crystals, which are related to long-term diet irregularities, genetic factors and obesity and other factors. Gallbladder wall crystals generally have no obvious clinical symptoms, patients with cholecystitis, there will be right upper abdominal pain and other manifestations, aggravated by eating. When the size of the crystals becomes larger, it will cause irritation to the mucous membrane and cause pain, which may radiate to the right shoulder, and there will also be a loss of appetite. Crystals in the gallbladder wall are a precursor of gallbladder stones and are mainly detected by ultrasonography. It is recommended to actively consult a doctor to formulate a treatment plan according to the specific condition.