In nucleic acid testing, the main difference between a negative and a positive virus test is the presence of a viral infection, and in the case of hepatitis B virus antibody testing, the difference between a positive and a negative test is the presence of antibodies in the body. The significance of negative and positive is different for different methods of virus testing. For example, in the nucleic acid test, the result of the virus test is negative, suggesting that there is currently no infection of the virus in the body and no previous infection of the virus. If the test result shows positive, it suggests that the person’s body is currently infected with the virus or has been infected with the virus before. However, if the patient is tested for antibodies to the hepatitis B virus, a negative result indicates that there is no immunity to the hepatitis B virus and vaccination is required. Positive indicates the presence of hepatitis B antibodies and will not have hepatitis B. Patients need to determine their condition under the guidance of the doctor according to the test items and test results, and do not need to worry too much and actively cooperate with the doctor for treatment.