Song 25-year-old male, Ichuan people, because of the lack of contraception and infertility 2 years to the clinic, in the field several times to check the semen routine are not sperm, said before marriage had been pregnant once, early pregnancy pedestrian abortion. 2 years ago the patient followed his uncle to work in Hebei, suffering from acute mumps led to bilateral testicular inflammation, because to private hospitals, delayed the disease, testicular inflammation has not been eliminated, 15 days before the local people’s hospital to give antibiotic treatment, the condition gradually His condition gradually improved and he was discharged from the hospital. In the following two years, he had a normal sex life without contraception and was still infertile, so he went to the local hospital to check his semen and no sperm was found. He was referred to our department by an acquaintance and was found to have normal sized but hard testes on both sides. The proposed diagnosis was: 1. secondary infertility 2. non-obstructive azoospermia. After full communication with the patient, testicular fine needle sperm retrieval was performed. Due to the hyaline degeneration of testicular tissue caused by orchitis, he was advised to give up treatment, but the patient and his family requested treatment. HCG 2000U + HMG 75U was given in combination to stimulate and promote sperm production in the testes. If HCG alone is used, it only promotes the secretion of androgens by the mesenchymal cells of the testes, but not by the supporting cells, and sperm production needs the combined action of mesenchymal cells and supporting cells to be produced properly. At the same time, the patient was treated with Chinese herbal medicine to identify the evidence and given Blood Mansions and Blood Stasis Soup + Wu Zi Yan Zong Wan plus reduction treatment. After three months of treatment, the patient and his brother came to the clinic and a small amount of motile sperm could be seen in the semen. The patient was very happy that he could have his own children in the future. Case analysis, because the patient’s mumps caused acute inflammation of the testis, and delayed treatment, resulting in gradual transparent deformation of testicular tissue, transparent deformation of the varicocele and interstitial small vessels, which can seriously affect the normal exchange of substances between the varicocele and interstitial, affecting the microenvironment of varicocele spermatogenesis, affecting spermatogenesis. The combined use of HCG and HMG can improve the microenvironment of spermatogenesis and facilitate spermatogenesis again. The combination of HCG and HMG can improve the microenvironment of spermatogenesis and facilitate spermatogenesis. Meanwhile, the treatment with Chinese herbal medicine, according to the ancestral medicine, this condition belongs to stagnation of blood.