Coughing at night after lying down and sitting up, the symptoms may be due to bronchitis and other respiratory diseases, chronic heart failure and other heart diseases, gastroesophageal reflux disease and other digestive diseases, can be intervened through the use of anti-infective, phlegm, asthma, diuretic, antacid medication, and other interventions. 1. Bronchitis and other respiratory diseases: when infectious diseases of the respiratory system occur, due to the increase of secretions in the trachea, the flow occurs after the change of body position, and then stimulate the mucous membrane of the trachea to produce cough. Intervention can be made by using anti-infective drugs such as cefuroxime, cough suppressants such as dextromethorphan, phlegmolytic drugs such as ambroxol hydrochloride, and asthmatic drugs such as aminophylline. 2. Chronic heart failure and other heart diseases: After lying down, the volume of blood returning to the heart increases, and the blood returning from the lungs to the heart is stagnant, resulting in pulmonary stasis, which may cause coughing. At this time, you need to rest in a semi-recumbent position or sitting position, and if necessary, you can inhale oxygen, and at the same time, you can use diuretics such as hydrochlorothiazide, renin angiotensin aldosterone inhibitors such as captopril, and beta-blockers such as metoprolol to intervene. 3. Gastroesophageal reflux disease (GERD) and other digestive diseases: stomach acid and other contents will flow back into the esophagus after lying down, stimulating the mucous membrane of the throat to cough. It can be treated by using antacid drugs such as omeprazole and gastric power drugs such as domperidone. If you have a cough that improves when you lie down and sit up at night, it is recommended that you go to the hospital in a timely manner. The above drugs need to be used under the guidance of a clinician, and unauthorized use of drugs is absolutely prohibited.