In recent years, with the increase in the incidence of breast cancer, the importance people attach to breast diseases, and the widespread development of health checkups, ultrasound has been widely used as one of the most popular and economical means of screening for breast diseases. And due to the high resolution of ultrasound, it is especially suitable for domestic women with small and dense breasts. As a result, many palpation-negative “nodules” are detected. Statistics show that 85% of breast lesions are detected by ultrasound. Although ultrasound can provide some information to determine benign or malignant, such as echoes, borders, blood flow, etc., ultrasound is only a clinical reference, not a final criterion for characterization. Therefore, the diagnosis of nodules brings new confusions and difficulties to both doctors and patients. For doctors, traditional surgical methods are inconvenient, even in the case of preoperative ultrasound localization requires a large incision to ensure the removal of the lesion, and as a result, after the lesion is diagnosed, the patient’s satisfaction is low due to scarring. How to have a method to diagnose nodules quickly, effectively and aesthetically is a problem that we have been trying to solve. On the other hand, the appearance of nodules also brings confusion to patients who come to the clinic for counseling, such as whether the nodules will grow in size under long-term observation? Will they become malignant? Especially for patients with solid nodules, high BIRADS stage, family history, and excessive stress and anxiety due to the appearance of nodules, a new tool is needed to confirm the diagnosis of nodules. Ultrasound-guided minimally invasive biopsies are an excellent solution to these problems, and ultrasound has become the most accurate and preferred guidance technique for minimally invasive biopsies. Ultrasound-guided minimally invasive biopsy is currently the most practical and effective biopsy method for “nodules”.