About 2.4% of the world’s population suffers from peripheral vascular disease of varying degrees, and ischemic necrosis of the lower limbs caused by the development of diabetes to a certain degree (diabetic foot) is a serious peripheral vascular disease. A famous professor of interventional vascular surgery in China said in an interview, “30% of diabetic patients will eventually develop diabetic foot and need amputation. And with the development of medical technology, modern surgical treatment tends to be minimally invasive, and interventional treatment can bring gospel to this part of patients.” Interventional treatment of the diabetic foot can save up to 80 percent of the limb Currently 285 million people worldwide suffer from diabetes, and according to the International Diabetes Federation, if the current rate of growth is not controlled, the total number of people with the disease will exceed 435 million by 2030. The treatment of diabetes has become a major issue for human health. “Interventional treatment can open up the occluded blood vessels of diabetic foot patients and improve blood supply through micro-balloon dilation and stent placement of lower limb vessels, which can significantly reduce the amputation rate and lower the amputation plane in diabetes, and the limb preservation rate can be over 80% by interventional surgery, and has the advantages of small trauma and quick recovery.” Interventional therapy is a direct and effective treatment for diabetic vascular lesions, and has great advantages as minimally invasive treatment, avoiding the higher risk of cardiovascular disease, short hospitalization period and easy to repeat. However, there is still a problem of postoperative restenosis and the probability of postoperative restenosis is higher in diabetic patients than in non-diabetic patients because of diabetes itself. The prevention and treatment of postoperative restenosis is also a hot topic today, such as the application of lower extremity-specific extra-long balloons, drug-eluting stents, endovascular irradiation, and other methods, as well as drug and gene therapy, which have been more studied in coronary artery stenosis. DF lesions due to diabetes often involve small arteries and affect microcirculation. Small arteries and microcirculation lesions cannot be resolved with catheters and guidewires, and must be combined with pharmacological treatment, via catheters or application of vasodilators and anticoagulants to improve microcirculation. Therefore, the use of anticoagulant drugs is very important. It is believed that with the continuous research on the prevention and treatment of restenosis after intervention, the application of interventional therapy combining multiple methods in diabetic foot will have a broader prospect.