Progesterone treatment may cause constipation because the main effect of progesterone is to relax the smooth muscle of the uterus. Since the whole body is a whole, since it relaxes the smooth muscle of the uterus, it may also cause relaxation of the smooth muscle of the gastrointestinal tract, which means that it slows down gastrointestinal motility. The slowing down of gastrointestinal motility will make the stool residue stay in the intestinal tract for a longer period of time, which will cause constipation. It is recommended that during the application of progesterone, appropriate dietary improvements can be made, such as eating more vegetables and fruits containing dietary fiber, which will improve the constipation.