Left side of the middle and lower abdomen pain intolerable may be intestinal lesions, urinary system diseases, gynecological diseases and so on. 1. Intestinal lesions: such as left hemicolonitis, sigmoiditis, sigmoid torsion, colon cancer, intestinal spasm, intestinal obstruction, etc., can cause intolerable pain in the left side of the middle and lower abdomen. 2. Urological diseases: such as left kidney stones, hydronephrosis, ureteral stones, etc., can also cause intolerable pain in the left side of the lower abdomen. 3. Gynecological diseases: women with left adnexitis, pelvic inflammatory disease, left tubal pregnancy rupture, left ovarian cyst torsion and other lesions, can also cause the left side of the middle and lower abdomen pain intolerable. There are many other causes of left-sided pain in the lower and middle abdomen, which should be taken seriously, and timely consultation should be made to identify the cause of the disease, and further treatment or therapy as prescribed by the doctor.