Clinically speaking, high glutamyl transferase is divided into transient elevation and persistent elevation, the former is mostly caused by food or drugs, and the latter is mostly caused by liver disease or bile duct obstruction and metabolic disorders. Glutamyltransferase mainly comes from the hepatobiliary system, as an important indicator of liver function, usually food or drug-induced poor secretion or excretion of the hepatobiliary system are temporary, eliminating the triggering factors can be restored. Persistent increase of glutamyltransferase is usually caused by liver diseases or biliary obstruction metabolic disorders, such as obstructive jaundice, acute and chronic hepatitis, cirrhosis, drug-induced liver damage, biliary tract infections, gallbladder stones, and hepatobiliary system occupational lesions, etc. Other diseases, such as myocardial infarction, acute pancreatitis, etc., can also cause increased glutamyltransferase, and the specific causes need to be combined with the patient history, clinical symptoms, imaging tests, liver puncture and other factors. The exact cause needs to be diagnosed by combining the patient’s medical history, clinical symptoms, imaging examination, and liver puncture.