Acupuncture on Ren Yu, Shen Que, Guan Yuan, and Shusan Li can improve the adverse effects caused by chronic lymphocytic leukemia and improve the quality of life. Chronic lymphocytic leukemia, referred to as chronic lymphoma, is a kind of hematopoietic system malignant tumor with unknown cause, which belongs to the category of “blood evidence” in Chinese medicine, and its etiology and pathogenesis are mostly caused by the body’s positive deficiency and evil attachment, and the evil poison enters into the medulla oblongata, and the treatment is based on the principle of supporting the positive and replenishing the deficiency. According to the meridian theory of Chinese medicine, Guanyuan is located in the lower jiao, through the foot shaoyin kidney meridian, Shenque is located next to the umbilicus, the place where the qi between the kidneys is moving, and Renyu belongs to the back of the kidneys, so acupuncture can warm and tonify the kidney qi, smooth the qi, and invigorate the function of the body, in order to regulate the nature of the innate; the foot is the foot yangming gastric meridian of the joint point, acupuncture can balance the yin and yang, and harmonize qi and blood, and is conducive to the function of the body recovery, in order to regulate the innate nature of the innate. The treatment of the above points should be operated by a professional acupuncturist and should not be used by oneself to avoid damage to the body.