The treatment after bone metastasis is mainly divided into two aspects: first, treatment for the symptoms caused by bone metastasis, which mainly manifests as pathological fractures and pain. Local surgical internal fixation or radiotherapy for pathological fractures can help reduce the risk of local fracture. Corresponding pain medications, such as non-steroidal anti-inflammatory drugs, morphine, and fentanyl, can be used for pain. In addition, it can also inhibit osteoclast activation and induce osteoclast apoptosis by zoledronic acid or disulfiramab, which can inhibit tumor cell growth and reduce bone destruction. Secondly, the main thing is to treat the primary disease that causes bone metastasis, such as bone metastasis caused by lung cancer, the treatment for lung cancer is very important. For bone metastasis caused by breast cancer, it is important to target radiotherapy, chemotherapy, endocrine therapy or targeted therapy for breast cancer. For colorectal cancer, surgical radical resection of colorectal cancer and post-operative chemotherapy are also beneficial for bone metastases.