Puffiness in the left ankle is most commonly associated with localized arthritis and joint hyperplasia, which can lead to significant swelling after trauma. Patients may also experience pain, especially in middle-aged and elderly patients, which may lead to aggravation of symptoms after activity. Therefore, we should pay attention to not straining, and we can do sports and exercise appropriately. We should also pay attention to elevating the limbs to improve the local blood circulation. If necessary, you can also take oral medications to regulate bone metabolism, apply glucosamine sulfate, and pay attention to calcium supplements, because osteoporosis also tends to induce local swelling due to osteophytes. In addition, local soft tissue injury caused by trauma or patients with ligament strains, chronic injury can also lead to local edema, and the patient will also have obvious aggravation after activity and pain performance.