The 52-year-old blood creatinine 125μmol / L if belongs to the physiological conditions such as strenuous exercise, etc., generally not serious; if the pathological factors such as gastrointestinal bleeding, urinary obstruction, glomerulonephritis, etc., is a more serious situation, the need for specific causes of targeted treatment. Normal reference values for blood creatinine are 53-106 μmol/L for men and 44-97 μmol/L for women. 125 μmol/L creatinine is not within the normal reference range for either men or women, and is an abnormality. It can be seen in physiological reasons such as: excessive intake of exogenous protein, strenuous exercise, muscular athletes, etc. may appear blood creatinine 125μmol / l, this is not serious, pay attention to light diet, regular review. Pathological conditions such as: gastrointestinal bleeding, cardiac insufficiency, drug damage, obstructive nephropathy, glomerulonephritis and so on, all belong to the more serious situation, need to be treated according to the specific cause, some cases such as gastrointestinal bleeding, cardiac insufficiency, remove the cause, creatinine may return to normal, but for the glomerulonephritis caused by the creatinine increase, generally can not return to normal. Abnormal creatinine results need to be treated in regular hospitals. Clinical professionals need to combine medical history, symptoms, signs and other auxiliary test results to make a comprehensive analysis and judgment, and then treat the disease in a timely manner to slow down the progress of the disease.