It is estimated that every woman in the preparation period will be more concerned about their own fertility, once into the state of preparation for pregnancy will be excited and anxious, after several failed attempts to look forward to will inevitably be doubly worried and confused. Today we are going to talk about some common factors that affect or even block women’s conception, and how to face and look at these “paper tigers”, the ultimate goal is to “know that there is a tiger in the mountain but not to the tiger’s mountain”, so that we can get the “good news” as soon as possible! The ultimate goal is to be aware of the “tigers” and not to walk towards them, so that we can get the “good news” as soon as possible and avoid the baby we are waiting for from becoming the “star” that we can’t pick. The first and well-deserved place in the list is age. Age is one of the indicators of reproductive potential that seems to have a love-hate relationship with patients and doctors alike. As women age, the quality and quantity of follicles decreases significantly. Current research suggests that the effects of ovarian aging on mitochondrial biogenesis, morphology, and function may contribute to the decline in oocyte function; in addition to the deleterious effects on transcriptional activities necessary to direct cytoplasmic maturation, meiosis, and translational processes in the oocyte. The success rate of assisted reproductive technology is closely related to the woman’s age and ovarian reserve status. Generally, the number of eggs in older women decreases after the age of 35. Women under 35 years old have good ovarian function and the cumulative clinical pregnancy rate of in vitro fertilization-embryo transfer (IVF-ET) can reach 60% to 70%, or even higher. 35 years old belongs to the advanced reproductive age, and the fertility declines rapidly, so the success rate of assisted reproduction technology is significantly lower, and the clinical pregnancy rate is 30% at the age of about 38 years old, while the clinical pregnancy rate at the age of over 40 years old is 30%, and the success rate of assisted reproduction technology is 30%. The clinical pregnancy rate is 30% at 38 years of age and only 15% or less at 40 years of age and above. Age as the most important indicator of reproductive potential, I hope that women with reproductive needs do not miss the best age of reproduction, reasonable planning for their own age of preparation for pregnancy, do not appear to be looking forward to the sigh of regret. “Yinhan long endured to take care of the magpie bridge road?” The second fallopian tube. The fallopian tube is the “magpie road” for sperm and egg to get pregnant naturally. It is the place where the “golden wind” and “jade dew” meet, and is the hotbed for the birth of life and the initial stage of growth and development, where the metamorphosis of the fertilized ovum combining and developing into a splintered ball is completed, and where it spends 72 hours growing into an early blastocyst, which enters the more nutritious and fertile uterine cavity. The uterine cavity is more fertile. After analyzing the factors of infertility, it was found that about 25% of infertility is associated with tubal obstruction and adhesions. Factors contributing to tubal pathology include infections (mainly Chlamydia trachomatis, tuberculosis), hydrosalpinx, endometriosis, history of pelvic surgery, and, rarely, fibroids. Therefore, in ordinary life, women should pay attention to this “bridge”, pay attention to hygiene, avoid or reduce unnecessary abortion, love and protect the fallopian tubes, this piece of holy land of life. The third ovulation disorder in the appointment of the birth of life, sometimes the egg Miss cool will always let the sperm doubly disappointed. Common causes of ovulation disorders include hypothalamic-pituitary amenorrhea, hyperprolactinemia, PCO (polycystic ovarian cysts), PCOS (polycystic ovary syndrome), insulin resistance, metabolic syndrome, adrenocortical hyperplasia, thyroid dysfunction, and luteinization of the follicles in the unruptured follicle syndrome. This shows that either the egg lady is undeveloped or she is shut down even though she is mature. Therefore, after repeated failures, you should go to a regular hospital for further examination to clarify the cause and free your eggs as soon as possible so that they can go to their appointments on time. Fertile soil endometrium On the 4th day after fertilization, the early blastocyst enters the uterine cavity and takes off the zona pellucida to develop into a late blastocyst which then lays down and continues to develop. At this point, the endometrium needs to be synchronized with the development of the embryo, and it needs to be as tolerant as possible, otherwise there will be difficulties in implanting the embryo, which will result in a failure. A successful pregnancy is not favorable when the endometrial thickness is “6 mm”. When the endometrial volume is less than 3 cm3, the clinical pregnancy rate decreases significantly. Endometrial and uterine abnormalities that affect endometrial thickness or embryo implantation include: uterine adhesions, multiple endometrial polyps, endometritis, endometrial hyperplasia, intrauterine fluid and submucosal fibroids, and uterine malformations. The importance of the lining of the uterus to pregnancy cannot be overstated, so uterine surgery should be minimized or avoided, such as repeated abortions undoubtedly produce varying degrees of damage to the lining of the uterus. Immunologic factors Immunologic factors may be the sole cause of infertility or may coexist with other causes to reduce fertility and temporarily cause infertility. The persistence of the infertile state depends on the interaction between immunity and fertility. Antibodies associated with infertility are anti-sperm antibodies, anti-endometrial antibodies, anti-ovarian antibodies, anti-HCG antibodies, anti-Zona pellucida antibodies, and anti-trophoblast membrane antibodies. About 50-60% of recurrent spontaneous abortions are also associated with immunologic factors, including autoimmune and isoimmune types. The presence of immune factors requires treatment by an immunologist. The male factor must be mentioned The incidence of infertility in China is reported to be 12.5% in the literature. The causes of male infertility include endocrine abnormalities, genetic factors, immunologic factors, sexual dysfunction, varicocele, spermatic duct abnormalities, congenital developmental abnormalities of the reproductive organs, chronic and nutritional disorders, environmental factors, and poor lifestyle habits. Therefore infertile couples must not be able to ignore or disregard the male factor in the examination. Through the above, on the basis of certain understanding, we hope that women will practice the protection of their own fertility health in their daily life, reasonably arrange their own pregnancy preparation plan, and seek professional and scientific help from the fertility center when there are difficulties in conception.