Those with stage II colon cancer combined with high risk factors such as poor tissue differentiation usually need chemotherapy, while patients in the low risk group usually do not need chemotherapy and can first observe their conditions regularly. Stage II colon cancer can be specific as the tumor penetrates the intrinsic muscular layer and reaches the plasma membrane layer; no lymph node and distant metastasis have occurred and other conditions. Surgical resection is usually feasible after diagnosis, and postoperative adjuvant chemotherapy should be decided in combination with whether or not high risk factors are combined. Postoperative chemotherapy is often not necessary for patients in the low-risk group, such as better histological differentiation, no vascular lymphatic infiltration, etc. On the contrary, in order to achieve better therapeutic effects, adjuvant chemotherapy is often required, commonly used chemotherapeutic drugs include oxaliplatin, fluorouracil, etc., and it is important to note that the drugs need to be applied under the guidance of a doctor.