There is generally no effect on children when men take entecavir. Entecavir is an antiviral drug that is mainly used to treat hepatitis B virus infection. No drug trials have shown that entecavir affects fertility, and there have been no clinical cases. To be on the safe side, alternative medications can be used, as well as proper screening during pregnancy. During the preparation for pregnancy, you can stop taking entecavir and switch to tenofovir after consulting your doctor because tenofovir can effectively inhibit the replication of hepatitis B virus and reduce the probability of mother-to-child transmission to a certain extent. According to the guidelines for the prevention and treatment of chronic hepatitis B, entecavir is classified as a class C drug and tenofovir is classified as a class B drug, which is safer in comparison. If you have an unplanned pregnancy while taking entecavir, you should not be too nervous. According to the “Guidelines for the Prevention and Treatment of Chronic Hepatitis B”, in case of unplanned pregnancy during the application of entecavir or adefovir, the pregnancy can be continued if the patient is fully communicated with, and the advantages and disadvantages are weighed, and the patient is required to switch to tenofovir or telbivudine to continue the treatment. Remind all the hepatitis B patients, do not blindly stop taking medication during the preparation for pregnancy, must switch to other drugs under the guidance of the doctor, the baby before birth to do a good job of liver function, DNA quantitative tests, and after birth to do a good job of vaccination, hepatitis B patients can also be conceived to a healthy baby.