X-barium meal angiography is the patient’s oral barium sulfate into the stomach and duodenum, using the barium can not be penetrated by X-ray, through the patient’s postural changes, observation of changes in the mucosa of the stomach and duodenum, to make the diagnosis of disease. At present, we mostly use air-barium double imaging to make judgment through the observation of mucosal phase and filling phase, which is also a common method to diagnose gastric and duodenal diseases. The advantages are that it is less painful and easy for patients to accept, but the disadvantages are that it is not as intuitive as gastroscopy, biopsy and pathological sectioning cannot be performed, and the barium is easy to constipate and cause intestinal obstruction due to the patient’s difficulty in defecation. barium X-ray meal imaging is mainly based on imaging changes, especially early gastroduodenal lesions are difficult to clarify and have certain limitations. It must be combined with gastroscopy to make early diagnosis and early treatment to avoid misdiagnosis and omission, which may cause irreparable damage and must be given great clinical attention.