Celecoxib and diclofenac sodium cannot be taken at the same time. Celecoxib and diclofenac sodium belong to the same class of drugs, that is, they are both non-steroidal anti-inflammatory drugs, drug effects, side effects are similar, the two together can not increase the effect of anti-inflammatory, pain relief, but will make the side effects doubled, and at the same time taking may cause gastric ulcers, perforation, bleeding, and liver and kidney dysfunction, and other serious adverse reactions. In the choice of pain medication, it is recommended that only one type of NSAID be chosen. If the pain relief effect is not satisfactory, it is recommended to consult a doctor in time and follow the doctor’s instructions to reasonably increase the dosage of the medication or shorten the interval between medications, but it is not recommended that two NSAIDs be used in combination. If the pain relief effect is still not achieved, it is recommended to adjust the pain relief program under the guidance of a doctor.