Hepatitis B virus less than 500 IU/mL is a normal result. There are two types of normal results: one is that the patient’s DNA value continues to drop after antiviral treatment and reaches the lower limit of the test value, which means that antiviral treatment is effective and needs to be continued and should not be discontinued indiscriminately. If you stop the medication in the middle of the process, it will cause the virus to replicate, which will lead to the rebound of the virus. There is also a situation where the patient is positive for hepatitis B surface antigen and is not on antiviral therapy, but is negative for hepatitis B DNA, so most of these patients are stable and do not need special treatment, and are generally reviewed twice a year. If there are other indicators that are abnormal, such as ultrasound or CT of the liver, a liver puncture is recommended for clarification. In addition, with the development of detection technology, the lower limit of hepatitis B DNA detection is now lower and lower, such as less than 15IU/ml, so patients with hepatitis B DNA less than 5.00E+02, those who are in a position to do so can use highly sensitive DNA testing methods to find out whether there is low-level replication of hepatitis B virus.