Chest pain in the middle of the chest with nausea may be due to esophagitis, gastritis, acute coronary syndrome and other causes. 1. Esophagitis: Due to low gastric motility, food reflux in the stomach may cause inflammation of the esophagus. Localized inflammation of the esophagus may also cause obvious symptoms of pain in the middle of the chest, especially after eating. 2. Gastritis: For patients suffering from gastritis, due to excessive secretion of gastric acid or the presence of Helicobacter pylori infection, the gastric mucosa will be damaged, which will cause pain in the middle of the chest, accompanied by nausea. 3. Acute coronary syndrome: for patients suffering from acute coronary syndrome, mostly due to coronary atherosclerosis to reduce the blood supply of the heart caused by the clinical symptoms, the patient will mostly appear in the middle of the chest pain, sternal pain, pressure and other symptoms. The causes of chest pain with nausea are many, it is recommended to go to the hospital in a timely manner, gastroscopy, electrocardiogram and other items to determine the cause of the disease, under the guidance of the doctor for the cause of the treatment.