Treatment of insulin resistance taking pioglitazone, it is recommended to follow the doctor’s instructions to take, the specific dosage time according to the condition of the decision. Pioglitazone belongs to the class of thiazolidinediones, which can activate the peroxidase proliferation activation receptor in human fat cells, muscle cells and hepatocytes, improve their conduction of insulin signals in the metabolic process, thus increasing the sensitivity to insulin. Pioglitazone enhances the action of insulin in the body without increasing the amount of insulin secreted by patients with type 2 diabetes. Pioglitazone may have adverse effects such as edema, headache, respiratory infections, and hypoglycemia. It is contraindicated in patients with a current or previous history of bladder cancer or in the presence of unexplained hematuria of the naked eye. If any of these adverse reactions occur, consultation with an endocrinology specialist is recommended for medication guidance.