Dry and sore throat at night may be associated with dry indoor environment, low water intake, chronic pharyngitis, obstructive sleep apnea hypoventilation syndrome and other primary conditions. General treatment, medication or surgery should be carried out according to the specific cause. 1. Dry indoor environment: When the indoor environment is too dry, it leads to faster loss of water in the mouth, causing dryness of oral mucosa and throat. Indoor air circulation can be strengthened, and humidifiers can be used to moisten the air and alleviate the symptom of dry and sore throat. 2. Drink less water: when the intake of water is less, the body does not have enough water, and the mucous membrane of the throat feels dry, you can supplement the body’s water, drink more water to relieve the symptoms. 3. Chronic pharyngolaryngitis: patients are mostly characterized by dry throat, sore throat, dry cough, foreign body sensation in the throat, need to quit smoking and alcohol, avoid dust, harmful gas stimulation, stay away from allergens, active treatment of chronic inflammation of the nasal cavity, sinuses, episodes of medication can be used, such as compound borax solution, furacillin solution and so on. 4. Obstructive sleep apnea hypoventilation syndrome: patients mostly snore during sleep, open-mouth breathing at night, air inhalation through the oropharynx, pharyngeal water disappears, and then dry and painful symptoms, need to treat the primary disease, through changing the sleep position or surgical treatment method for relief. Dry and painful throat may also be caused by other reasons, which can be treated under professional doctor’s advice, and the above medicines need to be used under doctor’s guidance.