Pitomod and splenic aminopeptide are both immunomodulators, need to be based on the patient’s own situation and condition under the guidance of the doctor’s reasonable use of medication, the specific effect of which drug can not be generalized. 1. Pitomod: a synthetic immunomodulator, suitable for patients with low immune function, used for chronic or recurrent respiratory tract and urinary tract infections adjuvant therapy. Adverse reactions such as nausea, vomiting, abdominal pain and diarrhea may occur during administration. Allergic to the product, children under 3 years old, pregnant women, patients with hereditary fructose intolerance are prohibited. 2. Splenic Amino Peptide: It is extracted from animal spleen and commonly used in the treatment of allergic rhinitis and chronic hepatitis B. However, due to its bidirectional immunomodulatory effect, the drug is also able to enhance or inhibit the functions of humoral immunity and cellular immunity. Its adverse reactions and contraindications are not clear. Both of these drugs have different effects and need to be rationally selected under the guidance of a doctor.