Key methods for early diagnosis of Parkinson’s disease: 1. Detailed and systematic medical history and physical examination: look for characteristic signs and symptoms of Parkinson’s disease. 2, standardized anti-Parkinson’s disease drug efficacy assessment: short-term hospitalization by the doctor according to the scale to assess the efficacy of the patient after taking drugs. 3.Brain nigrostriatal ultrasound: Initial screening for the presence of nigrostriatal lesions, but negative results cannot exclude Parkinson’s disease. 4.Brain molecular imaging: a more accurate and sensitive detection method.