The treatment program for osteoporosis in the elderly depends on the cause of the disease and the condition of the patient. In clinical practice, calcium supplementation is the mainstay of treatment, along with a combination of drugs to inhibit bone resorption, promote bone formation and other drugs. There is no optimal treatment for the time being.
1. Calcium supplementation: The calcium supplements used in the clinic are calcium carbonate, calcium lactate, calcium sulfate and active vitamin D. Calcium supplements are usually the first choice. Calcium is usually the drug of choice.
2. Drugs to inhibit bone resorption: mainly bisphosphonates, commonly used bisphosphonates in clinic are alendronate, risedronate, ibandronate and zoledronic acid. This class of drugs is currently the first-line drug. Estrogens and selective estrogen receptor modulators, mainly used in menopausal women. Nuclear factor-κB receptor activator ligand inhibitors and calcitonin.
3. Drugs promoting bone formation: parathyroid hormone and parathyroid hormone-related peptides can play a role in regulating bone metabolism. The main ones are teriparatide and abaloparatide. The duration of use of these drugs is recommended to be no longer than 24 months.
4. Other mechanism drugs: including active vitamin D and its analogs, anti-osteosclerotic protein monoclonal antibody, tetralin naphthoquinone, strontium ranelate and so on.
All of the above drugs are drugs for treating osteoporosis in the elderly, and some of them have strong toxic side effects, so it is important not to take them at the same time. It is recommended to seek professional medical help to customize individualized diagnosis and treatment plan, please use the drugs under the guidance of the doctor.