High ghrelin and ghrelinyltransferase may be caused by physiological reasons or pathologic reasons, such as liver disease, biliary tract obstructive disease, etc. 1. Physiological reasons: if patients drink a lot of alcohol for a long time, consume high protein supplements and food excessively, have too much pressure at work or in life, stay up late at night, and be overly fatigued, etc., all of them may increase the glutamine transaminase and glutamyl aminotransferase. 2. Pathologic causes: (1) Liver diseases: such as acute hepatitis, chronic active hepatitis, alcoholic hepatitis, as well as cirrhosis, primary and metastatic hepatocellular carcinoma, etc., all of them will have high alanine aminotransferase and glutamyl aminotransferase. (2) Biliary tract obstructive diseases: such as intrahepatic bile duct stones, primary biliary cirrhosis, as well as sclerosing cholangitis, obstructive jaundice, etc., all of which will cause high alanine aminotransferase and glutamyl aminotransferase. If there are abnormalities in ghrelin and ghrelinyltransferase, it is necessary to consult a doctor in time to clarify the cause of the disease and carry out standardized treatment, and do not abuse drugs without authorization, so as not to aggravate the condition.