There are some common “minor ailments” in dermatology that have limited symptoms but are not easy to treat, and sweat blisters are one example. The cause of this disease is not fully understood, in the past it was thought to be caused by sweaty hands and feet, and sweat was retained in the skin; now it is mostly thought to be an endogenous eczema-like skin reaction, and recently systematic allergy to metals such as nickel and chromium has been noted. Psychological factors may be one of the important causes of this disease. Clinical manifestations] The onset of the disease usually begins in late spring and early summer, intensifies in summer and heals spontaneously in winter. The typical damage is a small blister located deep in the epidermis, the size of a grain of rice, hemispherical, slightly above the skin surface, no inflammatory reaction, scattered or in groups on the palms of the hands, the sides of the fingers and fingertips, rarely seen on the back of the hands, the soles of the feet, often symmetrically distributed. The blisters contain clear plasma, shiny, and may occasionally become cloudy. The blisters usually do not rupture on their own and dry up to form peeling skin, revealing red new epithelium, thin and tender, which is often painful at this time. The surrounding skin is normal. The disease has varying degrees of pruritus and burning sensation. It often recurs periodically each year. It often needs to be differentiated from the following diseases: 1. Diseases: Tinea capitis: Symptoms: Tinea capitis is often present first and then tinea capitis, which is mostly one-sided and usually asymmetric. 2.Disease：Sweat sore type ringworm rash： Symptoms：Shallow blisters, thin wall of blisters, often active dermatophyte lesions, ringworm rash is self-healing after the lesions are cured, positive ringworm test. 3, disease: exfoliative keratolytic disease Symptoms: lesion performance is mainly epidermal exfoliation, very similar to sweating herpes, sometimes difficult to distinguish. But exfoliative keratolytic disease without obvious deep in small blisters. Treatment】 1, internal medication short course of oral prednisone, can be quickly effective, generally prednisone 30 mg daily, for 5-7 days. For emotionally stressed patients can apply appropriate sedatives. 2, external medicine early blistering damage treatment to dry itch, available l% phenol glycolate lotion or 3% ~ 5% formalin external application; the beginning of peeling corticosteroid cream or ointment, trenbolone urea ointment; local repeated peeling, on the dry pain, can be used externally 2% ~ 5% salicylic acid ointment, 10% urea ester, etc..