Gallbladder stones are a common disease caused by various pathological changes in the gallbladder caused by stones originating from the gallbladder. Some patients may have no clinical symptoms, so-called “asymptomatic gallbladder stones”, or “quiet” gallbladder stones; while others may present with significant “biliary colic “The rest of the patients may have only vague pain and discomfort in the right upper abdomen. Incidence and stone type: rare in children. Child patients with hemolytic disease are often combined with bile pigment type gallbladder stones. the incidence rises gradually above the age of 20 years, with a peak in women around 45 years; in men after menopause. The ratio of male to female is about 1:1.9. Adult gallbladder stones are mostly calcium cholesterol or calcium cholesterol + bilirubin mixed stones. Common clinical detection methods: 1, B-type ultrasonography can be more sensitive and accurate for census and detection of gallbladder stones; 2, MRCP (magnetic resonance cholangiopancreatography) can clearly show the structure of bile ducts and gallbladder inside and outside the liver, the size, number and distribution of stones, mainly used for gallbladder stones secondary to common bile duct stone disease. The initial stage (stage 1): it may be a single large cholesterol stone, or a large number of small stones. At this stage, the patient may have no obvious conscious symptoms or only mild atypical GI symptoms (such as epigastric or right upper abdominal pain and discomfort). Larger stones are less likely to become lodged in the neck of the gallbladder, so severe biliary colic (intermittent, paroxysmal right upper abdominal cramps, spreading to the right shoulder and back, often accompanied by nausea and vomiting; intermittent discomfort in the right upper abdomen or epigastrium) is less likely to occur. Most small stones are more likely to develop biliary colic symptoms in the early stages. Most small stones are more likely to have biliary colic symptoms at an early stage, and are very prone to secondary common bile duct stones and biliary pancreatitis. Such patients may have typical biliary colic and jaundice. Gallbladder complication stage (stage 2): It mainly depends on the mechanical factors of stones in the gallbladder. All complications are caused by stone obstruction. However, the degree and nature of pain varies from person to person. Depending on the degree of stone obstruction in the neck of the gallbladder and the severity of inflammation of the gallbladder, different degrees of biliary colic symptoms can occur. As the stone obstruction is relieved, the symptoms of biliary colic will be reduced or disappear accordingly. Extra-biliary complications stage (stage 3): due to the long-term location of stones in the gallbladder, causing repeated mechanical obstruction, infection, tissue necrosis, etc., various complications often occur. Commonly, there are: secondary common bile duct stones, intestinal fistula of gallbladder (duodenum, transverse colon); and about 0.5% incidence of gallbladder cancer. When choledocholithiasis is combined with biliary obstruction, yellow staining of the skin and sclera may occur, and combined with biliary tract infection, chills and fever may appear. In elderly patients with hypertension and arteriosclerosis, angina pectoris may occasionally cause symptoms similar to biliary angina. The biliary angina attack may also trigger angina pectoris (biliary heart syndrome). Biliary angina often occurs after eating fatty foods or after a full meal, but it can also occur without a specific trigger. However, when the stone is located in the jugular abdomen of the gallbladder in a semi-obstructed state, the attacks of angina are frequent and are closely related to diet. If the gallbladder stone is embedded in the jugular abdomen, the pain will not be relieved easily, and the symptoms of acute cholecystitis will appear. In recent years, there are many non-surgical treatments for gallbladder stones, including oral drug lithotripsy, contact lithotripsy, extracorporeal shock wave lithotripsy and so on. Other interventional treatments, such as percutaneous cholecystoscopic ultrasound lithotripsy, laparoscopic biliary stone extraction, small incision cholecystotomy for stone extraction, etc. All of them have the disadvantage of high stone recurrence rate due to the preservation of the hotbed of stone formation – pathological gallbladder. Most of the anti-inflammatory and cholestatic Chinese patent medicine preparations are effective in eliminating gallbladder inflammation. Sediment-like stones are more likely to be expelled; lumpy stones are smaller. Moreover, if they are discharged from the gallbladder, they enter the common bile duct. There is a risk of blocking the opening of the common bile duct, causing obstructive jaundice and inducing acute purulent cholangitis and acute pancreatitis. The main litholytic drugs are ursodeoxycholic acid. They need to be taken for a long time and are only effective for some patients with stones less than 1.0 cm in diameter, and have a certain impact on liver function; and they are prone to recurrence after stopping. Therefore, for most patients with gallbladder stones, laparoscopic cholecystectomy is still the first choice if there is a combination of cholecystitis and clinical symptoms.