Currently there is no criterion to distinguish between “symptomatic” and “asymptomatic” gallbladder stones, but the consensus is that gallbladder stones are “symptomatic” when they are combined with biliary colic, acute cholecystitis, bile duct obstruction, or pancreatitis. gallbladder stones. A systematic review from the Cochrane database confirms that there are no RCTs on the efficacy of prophylactic cholecystectomy for asymptomatic gallbladder stones. Foreign opinion in patients with asymptomatic gallbladder stones tends to discourage prophylactic cholecystectomy, and if prophylactic surgery is to be performed it should still be carefully considered in the context of the severity of the chronic disease and the patient’s hospital. Prophylactic cholecystectomy may be an option for elderly patients who may be at significantly increased risk of surgery during the expectant treatment period. Prophylactic cholecystectomy is mostly performed for asymptomatic gallbladder stones in the following conditions: 1. Gallbladder stones in diabetic patients. 2, non-functioning gallbladder. 3.Large gallbladder stones. 4, Porcelain gallbladder. 5.Gallbladder stones found during upper abdominal surgery. 6.Patients with gallbladder stones associated with diseases of the upper abdominal organs can undergo cholecystectomy at the same time during elective surgery.7 Patients with gallbladder stones with high risk factors for gallbladder cancer or suspected gallbladder cancer should be treated surgically regardless of the presence of symptoms.