Normally after pregnancy, estradiol decreases after 12 weeks of pregnancy, which is a normal physiological phenomenon. Estradiol can reach its peak around 8-10 weeks of pregnancy and start to decrease by 12 weeks. If there is no discomfort, this is nothing to worry about and no special treatment is needed. However, if estradiol decreases early in pregnancy, this may be a result of poor placental function, which can easily cause miscarriage, etc. If you have low estradiol, you should have an ultrasound to check the condition of the placenta. If you have abdominal pain or bleeding, you should take progesterone to protect the fetus, or you can also take diprogesterone tablets to regulate it. During pregnancy, pay attention to bed rest, no strenuous activities, and no spicy, stimulating food, it is recommended to eat more vegetables and fruits, which can keep the bowels open, if often constipated, it will aggravate the chances of miscarriage.