Large cell carcinoma of the lung is generally poorly treated, and patients may have an appropriate prolongation of survival time after surgical treatment. Lung large cell carcinoma is a kind of cancer without any morphological features, and the disease is highly malignant with poor treatment effect. Early-stage patients are usually treated with surgery, and if the patients’ condition is clearly advanced, they also need to be treated with auxiliary radiotherapy and chemotherapy. The prognosis of most patients is poor, and clinical data show that the 5-year survival rate of patients is 11.6%-21.4%, and the 5-year survival rate after surgery is about 30%. At the same time, patients usually need to actively regulate the diet, to ensure balanced nutritional intake, can be appropriate to eat more protein and vitamin-rich food. After surgery, patients should also take good care of themselves, develop good living habits, quit smoking in time, and under the guidance of doctors, undergo regular checkups to monitor the development of their conditions. It is suggested that patients with lung large cell carcinoma should actively cooperate with doctors to take systematic treatment, although it is difficult to be cured, they still need to face it positively and keep a good mindset.